Document Detail

The tissue-type plasminogen activator story.
MedLine Citation:
PMID:  19605778     Owner:  NLM     Status:  MEDLINE    
Milestones in the development of tissue-type plasminogen activator (t-PA) as a fibrin-specific thrombolytic agent include: purification of human t-PA from the culture fluid of the Bowes melanoma cell line, elucidation of the molecular basis of fibrin-specific plasminogen activation, first experimental animal models of thrombosis, first patient (renal allograft) treated with melanoma t-PA, pilot studies in patients with acute myocardial infarction, cloning and expression of recombinant t-PA providing sufficient amounts for large scale clinical use, and demonstration of its therapeutic benefit in large multicenter clinical trials.
D Collen; H R Lijnen
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  29     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-16     Completed Date:  2009-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1151-5     Citation Subset:  IM    
Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, O & N 1, Herestraat 49 Box 911, B-3000 Leuven, Belgium.
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MeSH Terms
Fibrinolytic Agents / history*,  therapeutic use
History, 20th Century
Recombinant Proteins / chemical synthesis,  history,  therapeutic use
Thrombolytic Therapy / history*,  methods
Thrombosis / blood,  drug therapy,  history*
Tissue Plasminogen Activator / chemical synthesis,  history*,  therapeutic use
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Recombinant Proteins; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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