Document Detail


The tissue effect of argon plasma coagulation on esophageal and gastric mucosa.
MedLine Citation:
PMID:  10968847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Argon plasma coagulation is a diathermy-based non-contact therapeutic endoscopic modality that may have a lower risk of perforation than other tissue ablation techniques. METHODS: Its effect was studied on three fresh esophageal and three fresh gastric resection specimens using power settings from 40 to 99 Watts at 90 degrees, with 1 mm separation using pulse durations of 1 and 3 seconds. A scoring system for depth of tissue damage was created and samples were analyzed blindly by a gastrointestinal histopathologist. RESULTS: There was significantly greater damage to gastric tissue using a 3-second (compared with 1-second) pulse (p = 0.003) and marginally significantly greater damage to esophageal tissue using the 3-second pulse (p = 0.053). Tissue damage was related to power setting for gastric (p = 0.031) but not for esophageal tissue (p = 0. 065). Only 1 of 42 esophageal samples and 2 of 42 gastric samples examined showed damage extending into the muscularis propria. CONCLUSIONS: Deep tissue damage that could lead to perforation was rare with argon plasma coagulation. The depth of gastric mucosal damage increased with increased pulse duration and increasing power settings, and, although the depth of esophageal mucosal damage was marginally related to pulse duration, it was not related to the power setting. (Gastrointest Endosc 2000;52:342-5).
Authors:
J P Watson; M K Bennett; S M Griffin; K Matthewson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  52     ISSN:  0016-5107     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-19     Completed Date:  2000-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  342-5     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / pathology,  surgery*
Aged
Carcinoma, Squamous Cell / pathology,  surgery*
Endoscopy, Digestive System*
Esophageal Neoplasms / pathology,  surgery*
Esophageal Perforation / prevention & control
Female
Gastric Mucosa / pathology,  surgery
Humans
Intestinal Mucosa / pathology*,  surgery
Intraoperative Complications / prevention & control
Laser Coagulation / methods*
Male
Middle Aged
Prognosis
Stomach Neoplasms / pathology,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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