Document Detail

The timing of tourniquet application in relation to prophylactic antibiotic administration.
MedLine Citation:
PMID:  3346316     Owner:  NLM     Status:  MEDLINE    
Antibiotic levels in bone and fat were measured in patients undergoing knee replacement to determine the time that should elapse between intravenous injection and tourniquet inflation. The tissue levels increased progressively with time, and there was wide variation in absorption rate between patients and between the two cephalosporins assessed. Five minutes should probably be left between systemic injection and inflation of the tourniquet, though two minutes may be long enough for drugs which are rapidly absorbed.
G C Bannister; J M Auchincloss; D P Johnson; J H Newman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  70     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-15     Completed Date:  1988-04-15     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  322-4     Citation Subset:  AIM; IM    
Winford Orthopaedic Hospital, Bristol, England.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*,  analysis
Knee Prosthesis*
Surgical Wound Infection / drug therapy,  prevention & control*
Time Factors
Reg. No./Substance:
0/Anti-Bacterial Agents

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