| The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development. | |
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MedLine Citation:
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PMID: 20331658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The consequences of prenatal maternal stress for development were examined in 125 full-term infants at 3, 6, and 12 months of age. Maternal cortisol and psychological state were evaluated 5 times during pregnancy. Exposure to elevated concentrations of cortisol early in gestation was associated with a slower rate of development over the 1st year and lower mental development scores at 12 months. Elevated levels of maternal cortisol late in gestation, however, were associated with accelerated cognitive development and higher scores at 12 months. Elevated levels of maternal pregnancy-specific anxiety early in pregnancy were independently associated with lower 12-month mental development scores. These data suggest that maternal cortisol and pregnancy-specific anxiety have programming influences on the developing fetus. |
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Authors:
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Elysia P Davis; Curt A Sandman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Child development Volume: 81 ISSN: 1467-8624 ISO Abbreviation: Child Dev Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-03-24 Completed Date: 2010-08-04 Revised Date: 2011-04-21 |
Medline Journal Info:
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Nlm Unique ID: 0372725 Medline TA: Child Dev Country: United States |
Other Details:
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Languages: eng Pagination: 131-48 Citation Subset: IM |
Affiliation:
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University of California, Irvine, USA. edavis@uci.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Anxiety / metabolism, psychology Child Development* Cognition* Female Gestational Age Humans Hydrocortisone / blood* Infant Infant Behavior / psychology Infant, Newborn Male Maternal-Fetal Exchange / physiology Mothers / psychology* Pregnancy Prenatal Exposure Delayed Effects / blood, psychology* Stress, Psychological / blood*, psychology |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000827-313040/RR/NCRR NIH HHS; NS-41298/NS/NINDS NIH HHS; R01 HD051852-03/HD/NICHD NIH HHS; R01 HD051852-04/HD/NICHD NIH HHS; R01 NS041298-05/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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