Document Detail

The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development.
MedLine Citation:
PMID:  20331658     Owner:  NLM     Status:  MEDLINE    
The consequences of prenatal maternal stress for development were examined in 125 full-term infants at 3, 6, and 12 months of age. Maternal cortisol and psychological state were evaluated 5 times during pregnancy. Exposure to elevated concentrations of cortisol early in gestation was associated with a slower rate of development over the 1st year and lower mental development scores at 12 months. Elevated levels of maternal cortisol late in gestation, however, were associated with accelerated cognitive development and higher scores at 12 months. Elevated levels of maternal pregnancy-specific anxiety early in pregnancy were independently associated with lower 12-month mental development scores. These data suggest that maternal cortisol and pregnancy-specific anxiety have programming influences on the developing fetus.
Elysia P Davis; Curt A Sandman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Child development     Volume:  81     ISSN:  1467-8624     ISO Abbreviation:  Child Dev     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-08-04     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0372725     Medline TA:  Child Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-48     Citation Subset:  IM    
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MeSH Terms
Age Factors
Anxiety / metabolism,  psychology
Child Development*
Gestational Age
Hydrocortisone / blood*
Infant Behavior / psychology
Infant, Newborn
Maternal-Fetal Exchange / physiology
Mothers / psychology*
Prenatal Exposure Delayed Effects / blood,  psychology*
Stress, Psychological / blood*,  psychology
Grant Support
M01 RR000827/RR/NCRR NIH HHS; M01 RR000827-313040/RR/NCRR NIH HHS; NS-41298/NS/NINDS NIH HHS; R01 HD051852/HD/NICHD NIH HHS; R01 HD051852-03/HD/NICHD NIH HHS; R01 HD051852-04/HD/NICHD NIH HHS; R01 NS041298/NS/NINDS NIH HHS; R01 NS041298-05/NS/NINDS NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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