| The timing of intra-coronary infusion of G-CSF mobilized peripheral blood stem cells influences cardiac function and in-stent restenosis in patients with myocardial infarction. | |
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MedLine Citation:
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PMID: 19203805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesized that delaying the timing of intra-coronary infusion of G-CSF mobilized stem cell until at least 4 weeks after coronary stenting should avoid the stimulation of vascular smooth muscle cells during the early active cellular proliferative phase, thus decreases in-stent restenosis while preserving the beneficial effect of stem cell therapy on cardiac function in patients with myocardial infarction (MI). 25 patients with ST-elevation myocardial infarction (STEMI) treated with stenting were enrolled in this pilot study. The ages of MI at the time of cell treatment were from 1 month to 59 months. At 6 months follow-up, the left ventricular ejection fraction (LVEF) increased from 32% to 37.7% and the stress thallium perfusion defect decreased from 31.4% to 28.1%. Cell treatment-related complications such as arrhythmias were not observed. 9 patients who underwent cell treatment less than 3 months after coronary stenting were evaluated for in-stent restenosis; it was found in only 1 patient. This pilot study shows that delayed more than 4 weeks after coronary stenting but less than 3 months after MI, intra-coronary infusion of G-CSF mobilized PBSCs may improve cardiac function without triggering in-stent restenosis. |
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Authors:
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Kyung-Soo Kim; Jiyong Jin; Young-Yiul Lee; Sung-Il Choi; Jin-Ho Shin; Jeong-Hyun Kim; Heon-Gil Lim; Bang-Hun Lee; Yun-Young Choi; Seok-Mo Lee; Hyun-Chul Koh |
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Publication Detail:
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Type: Clinical Trial; Letter; Research Support, Non-U.S. Gov't Date: 2009-02-08 |
Journal Detail:
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Title: International journal of cardiology Volume: 143 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 202-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Coronary Restenosis / therapy* Drug Administration Schedule Female Granulocyte Colony-Stimulating Factor / administration & dosage* Hematopoietic Stem Cell Mobilization / methods* Humans Infant Infant, Newborn Male Myocardial Infarction / therapy* Stents / adverse effects Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
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143011-72-7/Granulocyte Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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