Document Detail

The timing of cell-type-specific differentiation in Dictyostelium discoideum.
MedLine Citation:
PMID:  6724136     Owner:  NLM     Status:  MEDLINE    
We have used two-dimensional gel electrophoresis to identify over 30 proteins which are specific to one or other of the two cell types of Dictyostelium discoideum, either at the slug stage or in mature fruiting bodies. Our results support the idea that there is a continuous developmental program that begins in prespore cells at the hemispherical mound stage (10-12 hr) and results in spore differentiation (24 hr). Prestalk differentiation, on the other hand, appeared largely unrelated to stalk differentiation, which was first detectable at the onset of culmination (18 hr). We have also used this approach to study the differentiation of stalk-only mutants and have found that the cells can switch from spore to stalk differentiation as late as 2 hr before the end of the wild-type developmental program.
J H Morrissey; K M Devine; W F Loomis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental biology     Volume:  103     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-19     Completed Date:  1984-07-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  414-24     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation
Dictyostelium / cytology*,  genetics,  growth & development
Electrophoresis, Polyacrylamide Gel
Fungal Proteins / biosynthesis*,  isolation & purification
Methionine / metabolism
Phosphoproteins / metabolism
Spores, Fungal / metabolism
Time Factors
Grant Support
Reg. No./Substance:
0/Fungal Proteins; 0/Phosphoproteins; 63-68-3/Methionine

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