| The timing of cell-type-specific differentiation in Dictyostelium discoideum. | |
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MedLine Citation:
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PMID: 6724136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have used two-dimensional gel electrophoresis to identify over 30 proteins which are specific to one or other of the two cell types of Dictyostelium discoideum, either at the slug stage or in mature fruiting bodies. Our results support the idea that there is a continuous developmental program that begins in prespore cells at the hemispherical mound stage (10-12 hr) and results in spore differentiation (24 hr). Prestalk differentiation, on the other hand, appeared largely unrelated to stalk differentiation, which was first detectable at the onset of culmination (18 hr). We have also used this approach to study the differentiation of stalk-only mutants and have found that the cells can switch from spore to stalk differentiation as late as 2 hr before the end of the wild-type developmental program. |
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Authors:
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J H Morrissey; K M Devine; W F Loomis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental biology Volume: 103 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-07-19 Completed Date: 1984-07-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 414-24 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Differentiation Dictyostelium / cytology*, genetics, growth & development Electrophoresis, Polyacrylamide Gel Fungal Proteins / biosynthesis*, isolation & purification Methionine / metabolism Mutation Phosphoproteins / metabolism Phosphorylation Spores, Fungal / metabolism Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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GM23822/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins; 0/Phosphoproteins; 63-68-3/Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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