Document Detail

The timing of brain insults in preterm infants who later developed West syndrome.
MedLine Citation:
PMID:  11748495     Owner:  NLM     Status:  MEDLINE    
Abstract. The aim of this study is to clarify the timing of brain injuries in preterm infants who later developed West syndrome. We assessed the timing of brain insults with serial EEG recordings beginning immediately after birth in preterm infants less than 33 weeks of gestational age. The timing of brain insult was assessed by considering EEG findings in relation to the time of birth. The timing was considered prenatal if an EEG immediately after birth already showed chronic stage abnormalities, perinatal if it showed acute stage abnormalities, and postnatal if it was normal and a later EEG showed acute stage abnormalities. Eleven infants had periventricular leukomalacia and developed West syndrome. The timing of the brain insult was considered prenatal in 5 infants, perinatal in 2, postnatal in 2, prenatal plus postnatal in one, perinatal plus postnatal in one. The infants of less than 29 weeks of gestation were more likely to suffer brain damage postnatally, whereas those of more than 28 weeks tended to have brain injury prenatally. The timing of brain injury of preterm infants who later developed West syndrome is more often prenatal than generally considered.
A Okumura; K Watanabe; F Hayakawa; T Kato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuropediatrics     Volume:  32     ISSN:  0174-304X     ISO Abbreviation:  Neuropediatrics     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-12-18     Completed Date:  2002-02-11     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
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MeSH Terms
Brain Damage, Chronic / congenital*,  diagnosis
Gestational Age
Infant, Newborn
Infant, Premature, Diseases / diagnosis*
Leukomalacia, Periventricular / diagnosis
Risk Factors
Spasms, Infantile / diagnosis*

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