A time-dependent effect of caffeine upon lesion-induced plasticity. | |
MedLine Citation:
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PMID: 21664389 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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During a critical period, unilateral retinal lesions induce rapid axonal sprouting of intact axons into denervated territories within the collicular visual layers. We investigated the effect of caffeine, a non-selective A(1) and A(2a) antagonist, upon the lesion-induced plasticity of retinotectal axons. Pigmented rats submitted to a temporal retinal lesion received either caffeine (30mg/kg, ip) or saline treatment. The anterograde tracing revealed that caffeine treatment during the critical period resulted in a clear reduction on the sprouting of ipsilateral fibers but to an amplification of the plasticity after PND21, thus revealing opposite effects depending on the developmental time window. |
Authors:
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F Cabral-Miranda; C A Serfaty; P Campello-Costa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-1 |
Journal Detail:
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Title: Neuroscience research Volume: - ISSN: 1872-8111 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500749 Medline TA: Neurosci Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Programa de Neurociências, Departamento de Neurobiologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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