| A time-dependent effect of caffeine upon lesion-induced plasticity. | |
MedLine Citation:
|
PMID: 21664389 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
During a critical period, unilateral retinal lesions induce rapid axonal sprouting of intact axons into denervated territories within the collicular visual layers. We investigated the effect of caffeine, a non-selective A(1) and A(2a) antagonist, upon the lesion-induced plasticity of retinotectal axons. Pigmented rats submitted to a temporal retinal lesion received either caffeine (30mg/kg, ip) or saline treatment. The anterograde tracing revealed that caffeine treatment during the critical period resulted in a clear reduction on the sprouting of ipsilateral fibers but to an amplification of the plasticity after PND21, thus revealing opposite effects depending on the developmental time window. |
Authors:
|
F Cabral-Miranda; C A Serfaty; P Campello-Costa |
Related Documents
:
|
16374759 - Acoustic streaming in two endometriomas: the exception to the rule? 25113829 - The social amoeba polysphondylium pallidum loses encystation and sporulation, but can s... 6859459 - Secondary syphilis. clinical morphology and histopathology. 25175439 - Are parenchymal avms congenital lesions? 6967309 - Hamartomas of the cerebellopontine angle and internal auditory canal: report of two cases. 21587129 - Inflammatory pseudotumor suspected of lung cancer treated by thoracoscopic resection. 20446099 - Leptomeningeal dissemination of a pediatric neoplasm with 1p19q deletion showing mixed ... 8026829 - Remodeling of the alveolar structure in the paraquat lung of humans: a morphometric study. 12196779 - Clinical utility of eus-guided fine-needle aspiration of mediastinal masses in the abse... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-1 |
Journal Detail:
|
Title: Neuroscience research Volume: - ISSN: 1872-8111 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8500749 Medline TA: Neurosci Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
|
Programa de Neurociências, Departamento de Neurobiologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The improvement of a phenotype microarray protocol for the chemical sensitivity analysis of Streptoc...
Next Document: DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway.