Document Detail


Is tidal expiratory flow limitation predictive of sleep-related disorders in the elderly?
MedLine Citation:
PMID:  20378600     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sleep-related disorders represent an important health burden and their prevalence increases with age. In patients with snoring or sleepiness, the presence of expiratory flow limitation (EFL), determined via the negative expiratory pressure (NEP) method, is related to the apnoea/hypopnoea index (AHI). In this study, we examined whether EFL can be used to predict obstructive sleep apnoea syndrome (OSAS) in healthy asymptomatic older subjects. A group of 72-yr-old subjects (n = 448, 44% males) with a mean body mass index of 25.5±3.8 kg·m(-2) were examined. All subjects underwent spirometry, NEP (-5 cmH(2)O, sitting position) and ventilatory polygraphy (VP). Spirometry was within normal values in 88% of the group and EFL was present in 143 (32%) subjects with a higher prevalence in females (89 out of 249 versus 54 out of 199 in females and males, respectively). VP showed an AHI<15 h(-1) in 238 subjects (53%) and OSAS with an AHI ≥15 h(-1) in 47%. EFL was found in 15% of subjects with OSAS. Consequently, EFL had low sensitivity and specificity in the prediction of OSAS (31.4% and 67.7%, respectively). We conclude that the prevalence of EFL is elevated in healthy older subjects and cannot be used to predict the presence of sleep-related disorders in an older population.
Authors:
M Guillot; F Costes; E Sforza; D Maudoux; L Bertoletti; J C Barthélémy; F Roche
Publication Detail:
Type:  Journal Article     Date:  2010-04-08
Journal Detail:
Title:  The European respiratory journal     Volume:  36     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-03-10     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  842-8     Citation Subset:  IM    
Affiliation:
Service de Pneumologie et d'Oncologie Thoracique, CHU St Etienne, France.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00766584
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MeSH Terms
Descriptor/Qualifier:
Aged
Body Mass Index
Exhalation
Female
Geriatrics / methods
Humans
Male
Questionnaires
Respiration
Respiratory Function Tests
Sleep
Sleep Apnea, Obstructive / diagnosis,  etiology
Sleep Disorders / physiopathology*
Spirometry / methods
Tidal Volume*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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