| tiK+ toK+: an embryonic clock? | |
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MedLine Citation:
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PMID: 11545167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During embryogenesis cells make appropriately timed developmental decisions. Both 'hourglass-like' and 'clock-like' mechanisms have been demonstrated to act as timers in early development. The cell cycle rhythm, using feedback circuits to drive cells unidirectionally through checkpoints, is an example of a clock-like timer, but how it operates to time developmental events is unclear. In other cell types, cyclic oscillations in K+ channel activity, which parallel cell cycle and circadian rhythms, may be part of the timing mechanism. Changes in K+ oscillations accompany key developmental transitions and oncogenic transformation. Channel blockade interferes pharmacologically with cell cycle initiation or progression, whereas channel over-expression can be oncogenic. K+ channel activity also exists in early mouse oocytes through to at least the blastocyst stage, and it oscillates in phase with the developmental cell cycles, being high in M/G1 and low in S/G2. It resembles physiologically the activity of the K+ channels of the eag- or erg-like families. Reverse transcriptase-polymerase chain reaction of mouse oocytes has revealed the presence of transcripts encoding both EAG- and ERG-like proteins throughout preimplantation development. Channel activity continues to oscillate with a cell cycle periodicity in embryos from which the nucleus has been removed, or after inhibition by puromycin of the cyclin B-cyclin-dependent kinase 1 driven component of the chromosomal cycle. Channel oscillatory activity thus appears to be able to function autonomously of the chromosomal cycle and may represent a distinct oscillatory timing activity with possible developmental significance. |
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Authors:
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M L Day; N Winston; J L McConnell; D Cook; M H Johnson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Reproduction, fertility, and development Volume: 13 ISSN: 1031-3613 ISO Abbreviation: Reprod. Fertil. Dev. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-09-06 Completed Date: 2002-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8907465 Medline TA: Reprod Fertil Dev Country: Australia |
Other Details:
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Languages: eng Pagination: 69-79 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Sydney, NSW, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / genetics, physiology Embryonic and Fetal Development / genetics, physiology* Female Gene Expression Regulation, Developmental / genetics, physiology Humans Male Mice Potassium Channels / genetics, physiology* Pregnancy Time Factors Zygote / physiology |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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