Document Detail

The thyroid-stimulating hormone response to thyrotropin-releasing hormone in mania and bipolar depression.
MedLine Citation:
PMID:  6774358     Owner:  NLM     Status:  MEDLINE    
The release of thyroid-stimulating hormone (TSH) from the pituitary after infusion of 500 microgram of thyrotropin-releasing hormone (TRH) was decreased (p < 0.01) in manic patients and increased (p < 0.01) in bipolar depressed patients compared to a control group of patients with personality disorders. These results suggest that the TRH test may be useful in the diagnosis of psychiatric disorders and in the prediction of response to pharmacotherapy. We discuss the role of central monoaminergic systems in changes in the TSH response to TRH.
I Extein; A L Pottash; M S Gold; J Cadet; D R Sweeney; R K Davies; D M Martin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychiatry research     Volume:  2     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
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MeSH Terms
Affective Disorders, Psychotic / metabolism*
Bipolar Disorder / metabolism*
Personality Disorders / metabolism
Thyrotropin / metabolism*
Thyrotropin-Releasing Hormone / diagnostic use*
Reg. No./Substance:
24305-27-9/Thyrotropin-Releasing Hormone; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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