Document Detail

The thymus in Langerhans' cell histiocytosis.
MedLine Citation:
PMID:  10602868     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the frequency of thymic involvement in Langerhans' cell histiocytosis and describe its imaging appearance before and after treatment. MATERIALS AND METHODS: A retrospective review of the radiology and clinical records of all patients diagnosed with Langerhans' cell histiocytosis at DeVos Children's Hospital between 1992 and 1998. RESULTS: Of the 14 patients diagnosed with Langerhans' cell histiocytosis, 7 demonstrated multisystem involvement. The thymus was involved in 5 of 7 patients. The thymus was enlarged in 5; thymic contours were nodular/lobulated in 2; cystic changes were noted in 4; and dystrophic vascular-appearing calcifications were seen in 1. In all cases, findings regressed or resolved following chemotherapy. CONCLUSION: The thymus is commonly involved in Langerhans' cell histiocytosis, especially in multisystem disease. Radiologically, the thymus is enlarged and may be smooth or lobulated/nodular in contour, possibly containing cysts and calcifications.
J J Junewick; N E Fitzgerald
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric radiology     Volume:  29     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  904-7     Citation Subset:  IM    
DeVos Children's Hospital, Grand Rapids, MI 49503, USA.
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MeSH Terms
Child, Preschool
Histiocytosis, Langerhans-Cell / radiography*
Radiography, Thoracic
Retrospective Studies
Thymus Gland / radiography*
Tomography, X-Ray Computed

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