Document Detail

The thymus in Langerhans' cell histiocytosis.
MedLine Citation:
PMID:  10602868     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the frequency of thymic involvement in Langerhans' cell histiocytosis and describe its imaging appearance before and after treatment. MATERIALS AND METHODS: A retrospective review of the radiology and clinical records of all patients diagnosed with Langerhans' cell histiocytosis at DeVos Children's Hospital between 1992 and 1998. RESULTS: Of the 14 patients diagnosed with Langerhans' cell histiocytosis, 7 demonstrated multisystem involvement. The thymus was involved in 5 of 7 patients. The thymus was enlarged in 5; thymic contours were nodular/lobulated in 2; cystic changes were noted in 4; and dystrophic vascular-appearing calcifications were seen in 1. In all cases, findings regressed or resolved following chemotherapy. CONCLUSION: The thymus is commonly involved in Langerhans' cell histiocytosis, especially in multisystem disease. Radiologically, the thymus is enlarged and may be smooth or lobulated/nodular in contour, possibly containing cysts and calcifications.
J J Junewick; N E Fitzgerald
Related Documents :
6862518 - A study of cells present in lymph draining from a contact allergic reaction in pigs sen...
3876908 - Immunotopography of splenic lymphoma of small cleaved b-cell type.
11970978 - Matrix metalloproteinases 9 and 2 are necessary for the migration of langerhans cells a...
22033268 - A novel method for isolating individual cellular components from the adult human distal...
7274398 - Changes in gastric parietal cells during prolonged intermittent corticosteroid treatment.
17708338 - An immortalized rat ventral mesencephalic cell line, rtc4, is protective in a rodent mo...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric radiology     Volume:  29     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  904-7     Citation Subset:  IM    
DeVos Children's Hospital, Grand Rapids, MI 49503, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Child, Preschool
Histiocytosis, Langerhans-Cell / radiography*
Radiography, Thoracic
Retrospective Studies
Thymus Gland / radiography*
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The diagnostic value of intrarenal colour duplex Doppler ultrasonography in children with lower urin...
Next Document:  Reinsertion of accidentally removed tunneled central venous catheter via the existing subcutaneous t...