Document Detail

The thymus gland in elderly patients with myasthenia gravis.
MedLine Citation:
PMID:  1167640     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On microscopic examination, 11 patients had no thymic tissue. The other nine patients, including the one with thymectomy, all showed marked involution of the thymus. No germinal centers were seen. The thymus glands of two additional patients, still alive after thymectomy at ages 62 and 70, showed similar findings. Marked involution of the thymus also was found in each of six elderly controls. Thymectomy is not likely to be effective treatment of the elderly myasthenic patient.
V P Perlo; B Arnason; B Castleman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  25     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-05-21     Completed Date:  1975-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  294-5     Citation Subset:  IM    
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MeSH Terms
Middle Aged
Myasthenia Gravis / pathology*,  therapy
Thymus Gland / pathology*,  surgery

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