Document Detail

Is thrombophilia a risk factor for placenta-mediated pregnancy complications?
MedLine Citation:
PMID:  22543699     Owner:  NLM     Status:  Publisher    
PURPOSE: To determine if thrombophilia is a risk factor for placenta-mediated pregnancy complications (PMPC) (i.e., preeclampsia, intrauterine growth restriction (IUGR), placental abruption, intrauterine fetal death and recurrent pregnancy loss). METHODS: A 5-year retrospective cohort study. Ongoing pregnancies in women with an antecedent PMPC with thrombophilia were compared with the pregnancies in similar women without thrombophilia. The main outcome measures were mean birth weight deviations, corrected for gestational age, and recurrence of PMPC. Low-molecular-weight heparin (LMWH) was employed for thromboprophylaxis only. Mann-Whitney's, Fisher's and Chi-square tests were employed for comparison. RESULTS: PMPC recurred in 10/43 (23 %) in the thrombophilia group and in 7/41 (17 %) in the non-thrombophilia group, P < 0.059. The mean birth weight deviations were not significantly different either: -7.2 versus -3.0 %, respectively. LMWH, as could be expected, was used more often in thrombophilia patients (39/43 vs. 10/41, P < 0.001). CONCLUSION: Thrombophilia does hardly increase the risk of IUGR/PMPC or if so, it can be prevented by LMWH.
Elise Hoffmann; Elisabeth Hedlund; Trine Perin; Jens Lyndrup
Related Documents :
16726899 - Effect of egg yolk lipids on the freezing of goat semen.
22752609 - The pregnancy outcome in women with incidental diagnosis of septate uterus at first tri...
22660889 - The prevalence of preterm births in pregnancies complicated with fetal gastroschisis.
22509929 - Intravenous immunoglobulin treatment increased live birth rate in a spanish cohort of w...
3996619 - Intrauterine insemination: the university of minnesota experience.
3968649 - Prolonged survival of the graafian follicle and fertilization in the japanese greater h...
22940119 - The effect of progesterone supplementation on pregnancy rates in controlled ovarian sti...
384539 - Nutrition in pregnancy--1978.
11272409 - Effect of intraamniotic vitamin a on palatal closure of fetal rats.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-28
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  -     ISSN:  1432-0711     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, Roskilde University Hospital, 4000, Roskilde, Denmark,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Use of progestogens in pregnant and infertile patients.
Next Document:  Parasitological examination for presence of hookworms (Uncinaria spp.) in northern elephant seals (M...