Document Detail


The thrifty lipids: endocannabinoids and the neural control of energy conservation.
MedLine Citation:
PMID:  22622030     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The 'thrifty gene hypothesis' posits that evolution preferentially selects physiological mechanisms that optimize energy storage to increase survival under alternating conditions of abundance and scarcity of food. Recent experiments suggest that endocannabinoids - a class of lipid-derived mediators that activate cannabinoid receptors in many cells of the body - are key agents of energy conservation. The new evidence indicates that these compounds increase energy intake and decrease energy expenditure by controlling the activity of peripheral and central neural pathways involved in the sensing and hedonic processing of sweet and fatty foods, as well as in the storage of their energy content for future use.
Authors:
Nicholas V DiPatrizio; Daniele Piomelli
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-05-22
Journal Detail:
Title:  Trends in neurosciences     Volume:  35     ISSN:  1878-108X     ISO Abbreviation:  Trends Neurosci.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-26     Completed Date:  2012-11-12     Revised Date:  2013-08-20    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  403-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Departments of Pharmacology, University of California, Irvine, School of Medicine, Irvine, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / physiology*
Cannabinoid Receptor Modulators / physiology*
Endocannabinoids*
Energy Intake / physiology*
Energy Metabolism / physiology*
Humans
Lipids*
Grant Support
ID/Acronym/Agency:
R01 DA012447/DA/NIDA NIH HHS; R01 DK073955/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Cannabinoid Receptor Modulators; 0/Endocannabinoids; 0/Lipids
Comments/Corrections

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