| The thrifty lipids: endocannabinoids and the neural control of energy conservation. | |
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MedLine Citation:
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PMID: 22622030 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The 'thrifty gene hypothesis' posits that evolution preferentially selects physiological mechanisms that optimize energy storage to increase survival under alternating conditions of abundance and scarcity of food. Recent experiments suggest that endocannabinoids - a class of lipid-derived mediators that activate cannabinoid receptors in many cells of the body - are key agents of energy conservation. The new evidence indicates that these compounds increase energy intake and decrease energy expenditure by controlling the activity of peripheral and central neural pathways involved in the sensing and hedonic processing of sweet and fatty foods, as well as in the storage of their energy content for future use. |
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Authors:
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Nicholas V Dipatrizio; Daniele Piomelli |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-21 |
Journal Detail:
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Title: Trends in neurosciences Volume: - ISSN: 1878-108X ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7808616 Medline TA: Trends Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Departments of Pharmacology, University of California, Irvine, School of Medicine, Irvine, CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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