Document Detail

The three thiamin requirements of the rat.
MedLine Citation:
PMID:  6447118     Owner:  NLM     Status:  MEDLINE    
Some nutrients are necessary parts of several different biochemical systems and are required for several different and measurable physiological functions. There are three measurable dietary requirements for thiamin in the rat. The largest is correlated with food intake and body weight gain data. A half-maximum response is produced by 7 micrograms of thiamin per day, and a maximum response is produced by a dose 2- to 4-times larger. The next requirement, showing a half-response at 1 microgram thiamin, relates to cardiovascular function. It is measured by the enlargement of the heart or by the rat bradycardia bioassay method for thiamin. The smallest requirement, occurring at 0.01 microgram thiamin, is associated with the nervous system responses characteristic of thiamin deficiency, and may be related to a variability in oxidative metabolism.
W O Caster; J S Meadows
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  50     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1980  
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
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MeSH Terms
Body Weight / drug effects
Cardiomegaly / etiology
Dose-Response Relationship, Drug
Heart Rate / drug effects
Nutritional Requirements
Polyneuropathies / etiology
Thiamine / administration & dosage,  physiology*
Thiamine Deficiency / complications
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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