Document Detail

The three polymorphic chains of human Hb-F studied in normal Italian newborns.
MedLine Citation:
PMID:  6208921     Owner:  NLM     Status:  MEDLINE    
Both the known polymorphisms of human Hb-F have been investigated here. Two similar groups of full-term newborns have been considered: pure F-globin has been studied by suitable fingerprinting techniques in the first group, while isoelectrofocusing techniques have been employed in the second. The results clearly indicate that G/A gamma polymorphism can be correctly determined with both the procedures, while the T/I gamma polymorphism cannot, because IEF is not sensitive enough towards low quantities of A gamma T chains. Moreover, in the first group of newborns, the A gamma T gene frequency (P) is 0.23, while the total G/A gamma ratio of both groups is about 7/3, the two data being in full agreement with those of the literature. Furthermore, additional reports show that the main functional parameters of the whole neonatal blood are not significantly different either in the presence or in the absence of A gamma T chains.
A Guerrasio; M T Bertero; C Fabris; P G Pich; C Oneglia; F Tosetti; E Rabino-Massa; G Ricco
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bollettino della Società italiana di biologia sperimentale     Volume:  60     ISSN:  0037-8771     ISO Abbreviation:  Boll. Soc. Ital. Biol. Sper.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1985-01-09     Completed Date:  1985-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506962     Medline TA:  Boll Soc Ital Biol Sper     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  1621-7     Citation Subset:  IM    
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MeSH Terms
Fetal Blood / analysis
Fetal Hemoglobin / genetics*
Infant, Newborn*
Polymorphism, Genetic*
Reg. No./Substance:
9034-63-3/Fetal Hemoglobin

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