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"Is this case of a very rare disease work-related?" A review of reported cases of Pacinian neuroma.
MedLine Citation:
PMID:  21082159     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: In response to a request for a medicolegal opinion from an orthopaedic technician with pacinian neuroma of the hand, we conducted a systematic review of reported cases designed to assess whether this rare disease could be considered to be work-related.
METHODS: We used Medline, Embase, Google Scholar, Google, and a manual search to identify reports of histologically confirmed pacinian neuroma of the hand manifesting after 15 years of age. Cases with available information (from article/authors) on personal history were considered eligible. We tabulated information on age/gender; localization and histopathologic features; signs/symptoms; history of local trauma; occupation, sports/hobbies or other physical exposures; right- or left-handedness; and outcome.
RESULTS: We found 44 eligible cases (including the present referral). Of these, 21 (48%) followed a trauma [<6 months from onset/presentation (N=7); 0.5-2 years from onset (N=6); ≥2 years from onset (N=7); and timing unknown (N=1)] involving the same anatomic site. Three of these 21 traumas definitely occurred at work, and a further 2 cases occurred at the site of definite work-related repetitive microtrauma.
CONCLUSIONS: The results reinforce the concept that pacinian neuroma of the hand can follow local trauma or repetitive microtrauma. Implicated traumas were either recent or remote, and they sometimes occurred while performing manual tasks at work. We concluded that the referred case could plausibly be considered work-related.
Francesca Zanardi; Robin Mt Cooke; Antonino Maiorana; Stefania Curti; Andrea Farioli; Roberta Bonfiglioli; Francesco Saverio Violante; Stefano Mattioli
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Publication Detail:
Type:  Journal Article     Date:  2010-11-17
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  37     ISSN:  1795-990X     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  Finland    
Other Details:
Languages:  eng     Pagination:  253-8     Citation Subset:  IM    
Università di Bologna, Unita Operativa di Medicina del Lavoro, Policlinico S.Orsola-Malpighi, via Pelagio Palagi, 9, I-40138 Bologna, Italy.
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