Document Detail


A third link connecting aging with double strand break repair.
MedLine Citation:
PMID:  17245130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Until recently, the connection between aging and DNA repair has rested on two classes of observation. First, DNA damage and unrepaired double-strand breaks (DSBs) accumulate with age. Second, several defects in DNA repair genes are associated with early onset of age-related diseases and other signs of premature aging. Now, a third link has emerged: The mechanisms by which cells repair DSB damage can change dramatically with age, shifting from simpler end-joining processes in younger organisms to homologous mechanisms in which missing genetic information is restored through use of a template. So far this third link between aging and DNA repair has only been observed in a small number of experimental systems, and cannot yet claim the generality of the other two. Here we review the evidence for this phenomenon and present new data testing models for the underlying causes. If the generality of age-related changes in DSB repair pathway usage can be established, it will provide a new insight into the underlying molecular basis of aging and how evolution has shaped these processes.
Authors:
William R Engels; Dena Johnson-Schlitz; Carlos Flores; Lisa White; Christine R Preston
Publication Detail:
Type:  Journal Article; Review     Date:  2007-01-28
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  6     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-03-01     Completed Date:  2007-04-09     Revised Date:  2007-06-28    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Affiliation:
Genetics Department, University of Wisconsin, Madison, Wisconsin 53706, USA. wrengels@wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Aging / genetics*
Animals
Cell Aging / genetics
DNA Breaks, Double-Stranded*
DNA Damage / genetics
DNA Repair / genetics*
DNA Replication / physiology
Humans

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