Document Detail

A thiophen-thiooxorhodamine conjugate fluorescent probe for detecting mercury in aqueous media and living cells.
MedLine Citation:
PMID:  20859604     Owner:  NLM     Status:  MEDLINE    
A rhodamine-based sensor RB-S2 was designed and synthesized by combination of the thiospirolacton chromophore and the thiophen ring block with high affinity to Hg(2+). Probe RB-S2 exhibits high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Hg(2+) in aqueous solution. In addition, fluorescent imaging of Hg(2+) in MCF-7 cells is also successfully demonstrated.
Yi Zhou; Xue-Yan You; Yuan Fang; Ju-Ying Li; Ke Liu; Cheng Yao
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-22
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  8     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-14     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  4819-22     Citation Subset:  IM    
College of Science and State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, P. R. China.
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MeSH Terms
Cell Line, Tumor
Cell Survival
Fluorescent Dyes / chemistry*
Mercury / analysis*
Microscopy, Fluorescence / methods
Rhodamines / chemistry*
Sensitivity and Specificity
Spectrometry, Fluorescence / methods
Thiophenes / chemistry*
Reg. No./Substance:
0/Fluorescent Dyes; 0/Rhodamines; 0/Thiophenes; 7439-97-6/Mercury

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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