| The thickness of multi-walled carbon nanotubes affects their lung toxicity. | |
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MedLine Citation:
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PMID: 22128750 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Two samples of highly pure multi-walled carbon nanotubes (MWCNTs) similar in hydrophobicity and surface reactivity were prepared with similar length <5 m but markedly different diameter (9.4 vs 70 nm). The samples were compared for their cytotoxic activity, uptake and ability to induce oxidative stress (ROS production and intracellular GSH depletion) in vitro in murine alveolar macrophages (MH-S). The in vivo toxicity was evaluated by measuring biochemical (LDH activity and total proteins) and cellular responses in bronchoalveolar lavage (BAL) after intra-tracheal instillation in rats. Both samples were internalized in MH-S cells. However, thin MWCNTs appeared significantly more toxic than the thicker ones, both in vitro and in vivo, when compared on a mass dose basis. The data reported herein suggest that the nanotube diameter is an important parameter to be considered in the toxicological assessment of CNTs. |
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Authors:
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Ivana Fenoglio; Elisabetta Aldieri; Elena Gazzano; Federico Cesano; Massimiliano Colonna; Domenica Scarano; Gianna Mazzucco; Angelo Attanasio; Youssef Yacoub; Dominique F Lison; Bice Fubini |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-30 |
Journal Detail:
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Title: Chemical research in toxicology Volume: - ISSN: 1520-5010 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807448 Medline TA: Chem Res Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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