Document Detail

Is there something special about palmitoleate?
MedLine Citation:
PMID:  23324899     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The fatty acid, palmitoleate (16:1 n - 7), has received a lot of attention in recent years for being 'lipokine' and for the first time, we review the evidence to determine if there is something special about palmitoleate in humans.
RECENT FINDINGS: Despite dietary intakes being low (<4% of total energy) palmitoleate is the second most abundant monounsaturated fatty acid in most, but not all, blood lipid pools and notably more abundant in adipose tissue. Thus, compared with other fatty acids, the palmitoleate content of lipid pools must be influenced by endogenous synthesis, which appears to be tissue and depot specific. We present a summary of dietary intervention studies of food components enriched in palmitoleate but this gives inconclusive results in regards to an impact on human metabolic regulation.
SUMMARY: To date, there is no strong evidence from human studies suggesting that palmitoleate has 'lipokine' effects. However, unlike other fatty acids, there is a clear tendency towards compartmentalization and tissue-specific formation of palmitoleate, which is intriguing and requires further investigation.
Leanne Hodson; Fredrik Karpe
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  16     ISSN:  1473-6519     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-08-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-31     Citation Subset:  IM    
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MeSH Terms
Cholesterol, LDL / blood
Fatty Acids, Monounsaturated / administration & dosage*,  blood*
Insulin Resistance
Metabolic Diseases / drug therapy
Nutritional Status
Randomized Controlled Trials as Topic
Subcutaneous Fat, Abdominal / chemistry,  drug effects
Grant Support
FS/11/18/28633//British Heart Foundation
Reg. No./Substance:
0/Cholesterol, LDL; 0/Fatty Acids, Monounsaturated; 209B6YPZ4I/palmitoleic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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