Document Detail

Is there a set of histologic changes that are invariably reflux associated?
MedLine Citation:
PMID:  15679411     Owner:  NLM     Status:  MEDLINE    
Many histologic changes have been described in the esophageal squamous mucosa in patients with gastroesophageal reflux disease (GERD), including dilated intercellular spaces, balloon cells, intrapapillary vessel dilation, elongated papillae, basal cell hyperplasia, acanthosis, intraepithelial eosinophils, Langerhans cells, and p53 protein overexpression. To define a set of histologic changes that are invariably reflux associated, we examined the histologic changes in esophageal specimens from normal controls, patients with GERD, patients without GERD but with a suspicion of other pathology, and patients with esophageal carcinoma. We also examined biopsy specimens from sites with differing endoscopic features, including cloudy white and reddened mucosa. A definitive set of reflux-associated histologic changes could not be defined from the small number of biopsy specimens examined in the present study. Histologic changes indicative of GERD are likely to be found somewhere in the esophagus in all patients with GERD, but these changes are nonspecific. A set of histologic changes that are invariably reflux associated may exist, but these changes are nonspecific. To develop a set of characteristic reflux-associated features, endoscopists may perform targeted biopsies from several sites with various endoscopic features and at different stages of disease.
Kaiyo Takubo; Naoko Honma; Gopi Aryal; Motoji Sawabe; Tomio Arai; Yasuo Tanaka; Ken-ichi Mafune; Katsuhiko Iwakiri
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  129     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-31     Completed Date:  2005-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  AIM; IM    
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakae-cho 35-2, Itabashi-ku, Tokyo 173-0015, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Biological Markers / analysis
Carcinoma / pathology
Carcinoma, Squamous Cell / pathology
Dilatation, Pathologic / pathology
Endoscopy, Gastrointestinal / methods
Esophageal Neoplasms / pathology
Esophagogastric Junction / blood supply,  pathology
Esophagus / blood supply,  pathology
Gastroesophageal Reflux / pathology*
Microcirculation / pathology
Mucous Membrane / blood supply,  pathology
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reactivity of organolanthanide and organolithium complexes containing the guanidinate ligands toward...
Next Document:  The genesis of Barrett esophagus: has a histologic transition from gastroesophageal reflux disease-d...