| Is there a set of histologic changes that are invariably reflux associated? | |
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MedLine Citation:
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PMID: 15679411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many histologic changes have been described in the esophageal squamous mucosa in patients with gastroesophageal reflux disease (GERD), including dilated intercellular spaces, balloon cells, intrapapillary vessel dilation, elongated papillae, basal cell hyperplasia, acanthosis, intraepithelial eosinophils, Langerhans cells, and p53 protein overexpression. To define a set of histologic changes that are invariably reflux associated, we examined the histologic changes in esophageal specimens from normal controls, patients with GERD, patients without GERD but with a suspicion of other pathology, and patients with esophageal carcinoma. We also examined biopsy specimens from sites with differing endoscopic features, including cloudy white and reddened mucosa. A definitive set of reflux-associated histologic changes could not be defined from the small number of biopsy specimens examined in the present study. Histologic changes indicative of GERD are likely to be found somewhere in the esophagus in all patients with GERD, but these changes are nonspecific. A set of histologic changes that are invariably reflux associated may exist, but these changes are nonspecific. To develop a set of characteristic reflux-associated features, endoscopists may perform targeted biopsies from several sites with various endoscopic features and at different stages of disease. |
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Authors:
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Kaiyo Takubo; Naoko Honma; Gopi Aryal; Motoji Sawabe; Tomio Arai; Yasuo Tanaka; Ken-ichi Mafune; Katsuhiko Iwakiri |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 129 ISSN: 1543-2165 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-31 Completed Date: 2005-07-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 159-63 Citation Subset: AIM; IM |
Affiliation:
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Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakae-cho 35-2, Itabashi-ku, Tokyo 173-0015, Japan. takubo@tmig.or.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Autopsy Biological Markers / analysis Biopsy Carcinoma / pathology Carcinoma, Squamous Cell / pathology Dilatation, Pathologic / pathology Endoscopy, Gastrointestinal / methods Esophageal Neoplasms / pathology Esophagogastric Junction / blood supply, pathology Esophagus / blood supply, pathology Gastroesophageal Reflux / pathology* Humans Microcirculation / pathology Mucous Membrane / blood supply, pathology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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