Document Detail

Is there a role for nitric oxide activity in cervicogenic headache?
MedLine Citation:
PMID:  17925165     Owner:  NLM     Status:  MEDLINE    
Cervicogenic headache (CEH) is a unilateral headache that can be provoked by neck movement, awkward head positions or pressure on tender points in the neck. The mechanisms underlying the stimulation of pain in CEH are not clearly known. In this study, we measured serum nitrate and nitrite levels as an index of nitric oxide (NO) activity in 15 patients with CEH during headache and headache-free periods and in 15 healthy controls. Total nitrate+nitrite levels were found to be higher in CEH patients during headache periods than in healthy controls (20.7+/-3.8 micromol/l vs 14.4+/-3.6 micromol/l, p<0.001), but not in CEH patients during headache-free periods (16.1+/-2.2 micromol/l) compared with the controls (p>0.05). In the patients with CEH, serum total nitrate+nitrite levels were found to be higher during headache periods than during headache-free periods (p=0.001). It can thus be hypothesized that the changes observed are a cause of the attack rather than a consequence of the disease process.
Nurten Inan; Gulsen Yilmaz; Hatice Surer; Ozlem Coskun; Serap Ucler; Leyla Cavdar; Levent E Inan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Functional neurology     Volume:  22     ISSN:  0393-5264     ISO Abbreviation:  Funct. Neurol.     Publication Date:    2007 Jul-Sep
Date Detail:
Created Date:  2007-10-10     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707746     Medline TA:  Funct Neurol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  155-7     Citation Subset:  IM    
Department of Anesthesiology, Ankara Training and Research Hospital, Turkey.
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MeSH Terms
Middle Aged
Nitrates / blood
Nitric Oxide / metabolism*
Nitrites / blood
Post-Traumatic Headache / blood,  metabolism,  physiopathology*
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide

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