Document Detail

Is there a role for leukotriene antagonists in the prevention of recurrent nasal polyps?
MedLine Citation:
PMID:  20431368     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The aim of this review is to provide the current available data for leukotriene receptor antagonists in the treatment of nasal polyps, the use in the postoperative therapy single or as an add-on to standard treatments. RECENT FINDINGS: Surgical treatment of nasal polyps was refined in the last 30 years by the introduction of functional endoscopic sinus surgery and nasal endoscopy for monitoring nasal polyp patients. As the relapse is the main challenge and as nasal steroids only delay it, a more efficient treatment is needed. Leukotriene antagonists have effects on asthma and allergic rhinitis; preliminary data show some benefits in nasal polyps. SUMMARY: In the surgery of nasal polyps, recurrence is the main problem. Steroids are the current standard therapy, but the limitations are obvious. The role of leukotrienes in the disorder of nasal polyps is well established now, and with the antagonists available, interest rose in treating nasal polyps. A total of 356 patients took part in several studies involving leukotriene antagonists in the nasal polyp population. Some studies have minor levels of evidence; the data show positive effects for patients in preoperative and postoperative studies and medical treatments. There were benefits as an add-on to steroids and data from allergic rhinitis studies also show possible synergism with antihistamines. There are hints for a positive effect on eosinophil inflammation, clinical symptom scores, nasal airflow, sneezing and postnasal drip. Although some effects are shown, more controlled studies are necessary for reliable data.
Gerd Rasp
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  10     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-5     Citation Subset:  IM    
Department of Otorhinolaryngology, Paracelsus Medical University, A-5020 Salzburg, Austria.
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MeSH Terms
Asthma / drug therapy*,  immunology,  physiopathology
Clinical Trials as Topic
Leukotriene Antagonists / therapeutic use*
Nasal Polyps
Recurrence / prevention & control
Rhinitis, Allergic, Perennial / drug therapy*,  immunology,  physiopathology
Rhinitis, Allergic, Seasonal / drug therapy*,  immunology,  physiopathology
Reg. No./Substance:
0/Leukotriene Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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