Document Detail


Is there a role for the incretin system in blood pressure regulation?
MedLine Citation:
PMID:  24470204     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Incretin-based therapies are now well established for diabetes management and are among the frontline agents for control of hyperglycemia. In addition to their antihyperglycemic effects, evidence is emerging on the role of these agents on blood pressure regulation, cardioprotective and renoprotective properties. Because of the pleiotropic nature of these affects, these agents could offer significant benefits with regards to the cardiorenal metabolic complications that are part of the diabetes and obesity epidemic in the United States and worldwide. We review the various known mechanisms or pathways by which incretin based therapy exerts its regulation of blood pressure with emphasis on novel mechanisms such as inflammation/immunomodulation and oxidative stress.
Authors:
Akhilesh Rao; Ravi Nistala
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current hypertension reports     Volume:  16     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  417     Citation Subset:  IM    
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