| Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients? | |
| | |
MedLine Citation:
|
PMID: 19095115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Damage control resuscitation (DCR) with early plasma in combat casualties requiring massive transfusion (MT) decreases early deaths from bleeding. METHODS: To ascertain the potential role of early plasma DCR in civilian MT, we queried a prospective traumatic shock database of 383 civilians. RESULTS: Ninety-three (24%) of the traumatic shock civilians received a MT, of which 26 (28%) died early, predominantly from bleeding within 6 hours. Comparatively, this early MT death cohort arrived in more severe shock and were coagulopathic (mean INR 2.4). In the critical period of MT (ie, the first 3 hours), these patients received 20 U of packed red blood cells (PRBCs) but only 4 U of fresh frozen plasma (FFP). They remained severely acidotic and their coagulopathy worsened as they exsanquinated. CONCLUSION: Civilians who arrived in traumatic shock, required a MT, and died early had worsening coagulopathy, which was not treated. DCR with FFP may have a role in civilian trauma. |
| | |
Authors:
|
Frederick A Moore; Teresa Nelson; Bruce A McKinley; Ernest E Moore; Avery B Nathens; Peter Rhee; Juan Carlos Puyana; Gregory J Beilman; Stephen M Cohn; |
Related Documents
:
|
6382135 - Postheparin plasma lipase activities and plasma lipoproteins in newborn infants. 8466265 - Double blind trial of recombinant human erythropoietin in preterm infants. 7422165 - Prophylactic transfusions in pregnant patients with sickle hemoglobinopathies: benefit ... 3938415 - Dispositions of di- and mono-(2-ethylhexyl) phthalate in newborn infants subjected to e... 3359605 - Direct determination of selenium in serum by graphite-furnace atomic absorption spectro... 1606395 - Intratracheal n-acetylcysteine use in infants with chronic lung disease. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: American journal of surgery Volume: 196 ISSN: 1879-1883 ISO Abbreviation: Am. J. Surg. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-12-19 Completed Date: 2009-01-06 Revised Date: 2009-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 948-58; discussion 958-60 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, The Methodist Hospital, Houston, TX, USA. famoore@tmh.tmc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Blood Component Transfusion / methods* Critical Care / methods Female Follow-Up Studies Humans Male Middle Aged Plasma Prospective Studies Time Factors Trauma Severity Indices Treatment Outcome Wounds and Injuries / diagnosis, therapy* Young Adult |
| Investigator | |
Investigator/Affiliation:
|
Janet McCarthy / ; Rachelle Babbitt Jonas / ; Joseph Johnston / ; Peter Lopez / ; Dian Nuxoll / ; Huawei Tang / ; Burapat Sangthong / ; Constantinos Constantinou / ; Patricio Polanco / ; Andrew B Peitzman / ; Stephanie Huls / ; Jeffrey L Johnson / ; Catherine C Cothren / ; Melissa Thorson / ; Alan Beal / ; Ronald G Pearl / ; Larry M Gentilello / ; Anthony A Meyer / ; Leann Anderson / ; Barbara Gallea / ; Diane Rupp / ; Becky Saar / ; Michelle McGraw / ; Virginia Diaz / ; Kristi Carlson / ; Greg Wheatley / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vena cava filter retrieval in therapeutically anticoagulated patients.
Next Document: Noninvasive Doppler ultrasonography for assessing cardiac function: can it replace the Swan-Ganz cat...