Document Detail

Is there a role of the Thr164Ile-beta(2)-adrenoceptor polymorphism for the outcome of chronic heart failure?
MedLine Citation:
PMID:  16783489     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The Thr164Ile-beta(2)-adrenoceptor (AR) polymorphism exhibits lower affinities for catecholamines and reduced basal and agonist-stimulated adenylyl cyclase activity in vitro. It has been suggested that patients with chronic heart failure (CHF) due to ischemic or dilated cardiomyopathy carrying the Thr164Ile-beta(2)AR polymorphism exhibit much more rapid progression to death or heart transplantation (HTX) than CHF-patients carrying the homozygous Thr164-beta(2)AR. This study aimed to further evaluate the role of the Thr164Ile-beta(2)AR in CHF. For this we hypothesized that the Thr164Ile-beta(2)AR variant should be more abundant in HTX-patients than in patients with stable CHF or healthy controls. METHODS AND RESULTS: We genotyped 309 HTX-patients, 520 stable CHF-patients and 328 healthy controls for the three beta(2)AR variants Arg16Gly, Gln27Glu and Thr164Ile. The prevalence of the Thr164Ile-beta(2)AR variant was not considerably different in HTX-patients (2.3%) from that in CHF-patients (1.9%) or healthy controls (2.1%). Similarly, the frequency of the minor Ile164-allele was f(-)=0.0106 in HTX-patients, f(-)=0.0096 in CHF-patients and f(-)=0.0113 in healthy controls. CONCLUSIONS: The prevalence of the hypofunctional Thr164Ile-beta(2)AR variant and the frequency of the Ile164-allele were almost identical in CHF-patients, who had undergone HTX, with those in patients with stable CHF or in healthy controls. Thus, the role of the Thr164Ile-beta(2)AR in CHF remains questionable.
Kirsten Leineweber; Gero Tenderich; Christina Wolf; Sören Wagner; Armin Zittermann; Miriam Elter-Schulz; Reiner Moog; Norbert Müller; Heinz-Günther Jakob; Reiner Körfer; Thomas Philipp; Gerd Heusch; Otto-Erich Brodde
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Publication Detail:
Type:  Journal Article     Date:  2006-06-16
Journal Detail:
Title:  Basic research in cardiology     Volume:  101     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-26     Completed Date:  2007-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Department of Pathophysiology, University of Essen School of Medicine, Hufelandstr. 55, 45147 Essen, Germany.
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MeSH Terms
Aged, 80 and over
Cardiac Output, Low / diagnosis*,  genetics*,  physiopathology
Case-Control Studies
Chronic Disease
Disease Progression
Gene Frequency
Heart Transplantation / physiology
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Receptors, Adrenergic, beta-2 / genetics*,  physiology
Reg. No./Substance:
0/Receptors, Adrenergic, beta-2

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