| Is there a relationship between zinc and the peculiar comorbidities of Down syndrome? | |
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MedLine Citation:
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PMID: 11915434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Zinc plays a central role in the immune system and has been found to be significantly reduced in people with Down syndrome. The effectiveness of zinc supplementation in people with Down syndrome has been reported with discordant results. A comparison was made between a range of clinical and biochemical variables and zinc levels in 120 individuals with Down syndrome. Two groups of participants, one with normal zinc levels and the second with low zinc levels, were compared on the following measures: growth hormone secretion, IgA and IgG antigliadin antibodies, presence of coeliac disease, T3, T4, fT3, fT4, TSH, hypothyroidism, hyperthyroidism, CD4/CD8 ratio, total immunoglobulins G and subclasses. No significant difference was found between the two groups, except for IgG4 which was, unexpectedly, significantly decreased in the group with normal zinc levels. In conclusion, an impairment of zinc blood level in individuals with Down syndrome does not necessarily impact on the organs and systems evaluated here. |
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Authors:
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Corrado Romano; Rosa Pettinato; Letizia Ragusa; Concetta Barone; Antonino Alberti; Pinella Failla |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Down's syndrome, research and practice : the journal of the Sarah Duffen Centre / University of Portsmouth Volume: 8 ISSN: 0968-7912 ISO Abbreviation: Downs Syndr Res Pract Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-27 Completed Date: 2002-10-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9508122 Medline TA: Downs Syndr Res Pract Country: England |
Other Details:
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Languages: eng Pagination: 25-8 Citation Subset: IM |
Affiliation:
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Unità Operativa Autonoma di Pediatria, Oasi Institute (IRCCS), Troina, Italy. cromano@oasi.en.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Autoimmune Diseases / diagnosis*, immunology CD4-CD8 Ratio Celiac Disease / diagnosis, immunology Child Child, Preschool Comorbidity Down Syndrome / diagnosis*, immunology Female Human Growth Hormone / blood Humans Hyperthyroidism / diagnosis, immunology Hypothyroidism / diagnosis, immunology Immunoglobulin A / blood Immunoglobulin G / blood Infant Male Middle Aged Reference Values Thyroid Hormones / blood Zinc / deficiency* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulin G; 0/Thyroid Hormones; 12629-01-5/Human Growth Hormone; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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