Document Detail

Is there a relationship between obesity and intracranial hypertension?
MedLine Citation:
PMID:  7627247     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intracranial hypertension and obesity have been reported in recent studies of patients with periorbital venous vasculitis. These findings indicate that obese patients should be investigated for signs of inflammation in serum and lumbar cerebrospinal fluid (CSF) pressure.
PATIENTS AND METHODS: Twenty obese females, aged 27-68 years participated in the study of associated symptoms, signs of inflammation in serum, intracranial hypertension and magnetic resonance imaging of the brain (MR). Twenty randomly selected age- and sex-matched females were also investigated for associated symptoms and MR as controls.
RESULTS: There were no statistically significant differences in associated symptoms and diseases except for infertility (P < 0.05) between the two groups. The values for orosomucoid, haptoglobin, IgG, IgM and tests for rheumatic and antinuclear factors were significantly increased in the obese group compared with normal values at the hospital. The lumbar CSF pressure was increased above 20 cm water in 79% and above 25 cm water in 42% in the obese patients. MR showed that the subarachnoidal space in the obese patients were significantly smaller than in the controls.
CONCLUSIONS: Signs of inflammation in serum, intracranial hypertension and decreased subarachnoidal space were statistically significantly more common in patients with obesity, than in controls.
J Hannerz; D Greitz; K Ericson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  19     ISSN:  -     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-09-05     Completed Date:  1995-09-05     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  240-4     Citation Subset:  IM    
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MeSH Terms
Antibodies, Antinuclear / blood
Brain / pathology
Cerebrospinal Fluid Pressure / physiology
Fatigue / complications,  physiopathology
Haptoglobins / analysis
Intracranial Pressure / physiology
Magnetic Resonance Imaging
Middle Aged
Obesity / blood,  complications,  physiopathology*
Orosomucoid / analysis
Pain / complications,  physiopathology
Pseudotumor Cerebri / blood,  complications,  physiopathology*
Vasculitis / complications,  physiopathology
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Haptoglobins; 0/Orosomucoid
Comment In:
Int J Obes Relat Metab Disord. 1995 Oct;19(10):762-3   [PMID:  8589774 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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