Document Detail


Is there a relationship between chronic bladder dysfunction and somatic symptoms in other body regions? 2. An experimental neuroanatomical approach.
MedLine Citation:
PMID:  16142554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Based on clinical description of associated dysfunctional symptoms in patients with non-neurogenic lower urinary tract dysfunction an experimental setup was created in order to investigate the neuroanatomical basis for the clinical phenomena observed. METHODS: Using 24 male adult Sprague-Dawley rats for retrograde mapping of the spinal cord and brain, a pseudorabies virus (PRV) tracer was subsequently injected into four pertinent locations; (a) the trigone, (b) the masseter muscle (c) the forepaw and (d) the hindpaw. RESULTS: PRV tracing demonstrated clearly overlapping of labeled areas in the brain stem, diencephalon and thoracic-lumbar cord, from all injection sites of the rats. CONCLUSION: There is a diffuse overlap within the brain stem and spinal cord, of autonomic innervation to peripheral tissues based on the presented animal experiments. The described autonomic network allows an understanding of the occurrence of symptoms in distant regions of the body associated to chronic bladder dysfunction.
Authors:
Dirk-Henrik Zermann; Manabu Ishigooka; Jörg Schubert; Richard A Schmidt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International urology and nephrology     Volume:  37     ISSN:  0301-1623     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-05     Completed Date:  2006-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  263-73     Citation Subset:  IM    
Affiliation:
Neuro-Urology Lab and Neuro-Urology Unit, Department of Urology, University of Colorado Health Science Center, Denver, CO, USA. dh.zermann@med.uni-jena.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Nervous System / virology*
Autonomic Nervous System Diseases / complications*
Central Nervous System / virology*
Herpesvirus 1, Suid / isolation & purification*
Male
Rats
Rats, Sprague-Dawley
Urinary Bladder Diseases / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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