| Is there a pre-RC checkpoint that cancer cells lack? | |
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MedLine Citation:
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PMID: 16880740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Critical for genomic integrity, accurate DNA replication is tightly regulated by the convergence of prereplication protein complexes (pre-RCs) to "license" replicating origins on DNA in G(1) and is activated by S-phase promoting kinases that selectively target and trigger origin firing in S-phase. To present, a checkpoint mechanism monitoring pre-RC complex formation and activation has yet to be elucidated. However, perturbation of these protein complexes has yielded divergent phenotypes in recent reports: normal cells arrest in the cell cycle, whereas cancerous cells arrest and die. These data implicate a mechanism by which normal cells sense pre-RC deficiency and then signal for cell cycle arrest. The potential for therapeutic exploits of this disparity between normal and cancer cells is apparent. Here, we explore recent data supporting the existence of a pre-RC checkpoint that ensures faithful pre-RC formation, a cell cycle mechanism that is intriguingly compromised in cancer cells. |
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Authors:
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Eric Lau; Wei Jiang |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-08-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 5 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-24 Completed Date: 2007-01-03 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 1602-6 Citation Subset: IM |
Affiliation:
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The Burnham Institute for Medical Research, La Jolla, California 92037, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA Replication / physiology* Humans Models, Biological* Neoplasms / genetics, pathology*, therapy |
| Grant Support | |
ID/Acronym/Agency:
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2T32 CA77109-06A2/CA/NCI NIH HHS; CA97950/CA/NCI NIH HHS; GM67859/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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