| Is there a place for corifollitropin alfa in IVF/ICSI cycles? A systematic review and meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 22277766 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the role of corifollitropin alfa, a newly developed weekly administrated long-acting recombinant FSH (rFSH), as an alternative for daily rFSH administration in women undergoing controlled ovarian stimulation in GnRH antagonist down-regulated in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment cycles. DESIGN: Systematic review and meta-analysis of randomized controlled trials. SETTING: University and private centers. PATIENT(S): Infertile women undergoing IVF/ICSI treatment. INTERVENTION(S): Comparing long-acting rFSH corifollitropin alfa versus standard daily administrated rFSH in GnRH antagonist IVF/ICSI cycles. MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate, live birth rate, clinical pregnancy rate, miscarriage rate, duration of stimulation, amount of FSH, number of retrieved oocytes, number of mature oocytes, number of embryos obtained, fertilization rate, ovarian hyperstimulation syndrome (OHSS) incidence, and adverse events. Searches (of literature through November 2011) were conducted in Medline, Embase, Science Direct, the Cochrane Library, and databases of abstracts. RESULT(S): Four randomized trials involving 2,326 women were included. There was no evidence of a statistically significant difference in ongoing pregnancy rate for corifollitropin alfa versus rFSH. There was evidence of increased ovarian response and risk of OHSS in corifollitropin alfa. CONCLUSION(S): In view of its equivalence and safety profile, corifollitropin alfa in combination with daily GnRH antagonist seems to be an alternative for daily rFSH injections in normal responder patients undergoing ovarian stimulation in IVF/ICSI treatment cycles. |
| | |
Authors:
|
Mohamed Abdelfattah Mahmoud Youssef; Madelon van Wely; Ismail Aboulfoutouh; Walid El-Khyat; Fulco van der Veen; Hesham Al-Inany |
Related Documents
:
|
12634466 - The relationship of recurrent spontaneous miscarriage with reproductive failure. 7821506 - Postpartum ovarian veins thrombophlebitis. 22384436 - Comparison of mild ovarian stimulation with conventional ovarian stimulation in poor re... 21194826 - Ovarian tumours in pregnancy: a literature review. 9884486 - Surgical and pathologic observations of epididymal tubules during microscopic epididyma... 19138316 - Hyperparathyroidism during pregnancy and the effect of rising calcium on pregnancy loss... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-23 |
Journal Detail:
|
Title: Fertility and sterility Volume: - ISSN: 1556-5653 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Obstetrics and Gynaecology, Center for Reproductive Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt; Department of Obstetrics and Gynaecology, Center for Reproductive Medicine, Academic Medical Center, Amsterdam, the Netherlands; Egyptian International Fertility Center-IVF, Cairo, Egypt. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sphingosine pathway deregulation in endometriotic tissues.
Next Document: Polymorphisms of DNA Repair Pathway Genes and Cigarette Smoking in Relation to Susceptibility to Lar...