Document Detail

Is there a neural stem cell in the mammalian forebrain?
MedLine Citation:
PMID:  8873356     Owner:  NLM     Status:  MEDLINE    
Neural precursor cells have been of interest historically as the building blocks of the embryonic CNS and, most recently, as substrates for restorative neurological approaches. The majority of previous in vitro studies of the regulation of neural-cell proliferation by polypeptide growth factors, and in vivo studies of neural lineage, argue for the presence of precursors with limited proliferative or lineage potential in the mammalian CNS. This is in contrast to renewable tissues, such as the blood or immune system, skin epithelium and epithelium of the small intestinal crypts, which contain specialized, self-renewing cells known as stem cells. However, recent in vitro and in vivo studies from our and other laboratories lead us to conclude that neural stem cells, with self-renewal and multilineage potential, are present in the embryonic through to adult mammalian forebrain.
S Weiss; B A Reynolds; A L Vescovi; C Morshead; C G Craig; D van der Kooy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in neurosciences     Volume:  19     ISSN:  0166-2236     ISO Abbreviation:  Trends Neurosci.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-15     Completed Date:  1997-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  387-93     Citation Subset:  IM    
Dept of Anatomy, University of Calgary Faculty of Medicine, Alberta, Canada.
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MeSH Terms
Epidermal Growth Factor / physiology*
Models, Biological
Prosencephalon / cytology*,  growth & development
Stem Cells / physiology*
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor
Comment In:
Trends Neurosci. 1997 May;20(5):203-4   [PMID:  9141195 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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