| Is there a link between inflammation and abnormal lipoprotein profile in Sjögren's syndrome? | |
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MedLine Citation:
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PMID: 20378384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the lipoprotein profile of patients with primary Sjögren's syndrome (pSS) and its association with laboratory tests, including markers of inflammation. METHODS: This is a cross-sectional study among patients with pSS and healthy controls. We analyzed the lipoprotein profile of 73 pSS patients compared to 65 healthy individuals in the control group. We further evaluated possible associations between dyslipidemia in pSS patients and laboratory parameters including: hypergammaglobulinemia, autoantibodies [antinuclear antibodies (ANA), rheumatoid factor (RF), anti-Ro, anti-La], and acute-phase reactants [C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)]. RESULTS: Patients and controls were comparable regarding the demographic variables. Lipoprotein profile was similar between pSS patients and controls: total cholesterol (204.0+/-43.39 versus 206.5+/-42.76 mg/mL, P=0.73), LDL fraction (131.6+/-37.38 versus 130.62+/-38.24 mg/dL, P=0.88) and HDL fraction (49.7+/-13.5 versus 51+/-11.5mg/dL, P=0.56), triglycerides (129.3+/-81.0 versus 116.8+/-53.5mg/dL, P=0.29). However, patients with pSS had a strong trend to present dyslipidemia when compared to healthy individuals (76.7% versus 61.5%, P=0.06). The presence of dyslipidemia in pSS was associated with increased ESR (44.05+/-28.07 versus 28.28+/-18.00, P=0.03), but not with other laboratory markers of the disease and inflammation. DISCUSSION/CONCLUSION: pSS patients frequently present abnormal lipid profile, which are associated with higher levels of ESR. Thus, similar to other systemic inflammatory diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), lipid profile should be evaluated in pSS patients, with the aim of initiating specific therapeutic strategy for prevention of cardiovascular events. |
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Authors:
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Willian Cruz; Sonia Fialho; Edelton Morato; Gláucio Castro; Adriana Zimmermann; Giovana Ribeiro; Fabrício Neves; Ivânio Pereira |
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Publication Detail:
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Type: Journal Article Date: 2010-04-07 |
Journal Detail:
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Title: Joint, bone, spine : revue du rhumatisme Volume: 77 ISSN: 1778-7254 ISO Abbreviation: Joint Bone Spine Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-25 Completed Date: 2010-08-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100938016 Medline TA: Joint Bone Spine Country: France |
Other Details:
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Languages: eng Pagination: 229-31 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved. |
Affiliation:
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Rheumatology Division, Federal University, Santa Catarina, Florianópolis-SC, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies, Antinuclear / blood Biological Markers / blood* Blood Sedimentation C-Reactive Protein / metabolism Cross-Sectional Studies Dyslipidemias / blood, immunology* Female Humans Hypergammaglobulinemia / blood, immunology Inflammation / blood, immunology* Lipoproteins / blood* Male Middle Aged Rheumatoid Factor / blood Sjogren's Syndrome / blood, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/Biological Markers; 0/Lipoproteins; 0/SS-A antibodies; 0/SS-B antibodies; 9007-41-4/C-Reactive Protein; 9009-79-4/Rheumatoid Factor |
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