| Is there an interaction between cervical length and cervical microbiology in the pathogenesis of preterm labour? | |
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MedLine Citation:
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PMID: 11453267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transvaginal ultrasound of the cervix is increasingly used to estimate cervical length during pregnancy. Initially used to determine a possible need for cervical suture, the technique has been shown to be of value in the prediction of preterm delivery In addition, bacterial vaginosis has been shown to be associated with an increased risk of preterm delivery. We hypothesised that shortening of the cervix and potential cervical pathogens, in particular the presence of bacterial vaginosis, act synergistically in the pathogenesis of premature labour. Three hundred and sixteen women were recruited for prospective longitudinal follow-up, with both transvaginal ultrasound and cervical bacteriology performed at approximately 18 and 28 weeks gestation. A strong correlation was found between a shortened cervix and preterm delivery (p<0.02 at 18 weeks; p<0.001 at 28 weeks). Women with both a short cervix and cervical pathogens had the highest risk of preterm delivery (43%), although not significantly greater than a short cervix with normal cervical flora (31% preterm delivery). In the presence of a normal cervical length, preterm delivery rates in the presence of normal flora and potential cervical pathogens were much lower (9% and 5% respectively). |
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Authors:
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J Dowd; M Permezel; S Garland; L de Crespigny |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Australian & New Zealand journal of obstetrics & gynaecology Volume: 41 ISSN: 0004-8666 ISO Abbreviation: Aust N Z J Obstet Gynaecol Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-07-16 Completed Date: 2001-12-04 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0001027 Medline TA: Aust N Z J Obstet Gynaecol Country: Australia |
Other Details:
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Languages: eng Pagination: 177-81 Citation Subset: IM |
Affiliation:
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University of Melbourne, Department of Obstetrics and Gynaecology, The Royal Women's Hospital, Melbourne, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cervix Uteri
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anatomy & histology*,
microbiology*,
ultrasonography Female Gestational Age Humans Obstetric Labor, Premature / epidemiology, microbiology* Parity Pregnancy Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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