| Is there an ideal way to discontinue the ketogenic diet? | |
| | |
MedLine Citation:
|
PMID: 21536412 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
It is unclear what the ideal weaning speed of the ketogenic diet should be and the resultant risk of seizure worsening. A retrospective chart review was performed of children who discontinued the ketogenic diet at Johns Hopkins Hospital from January 2000 to June 2010. Speed of discontinuation was categorized into immediate (<1 week), quick (1-6 weeks), or slow (>6 weeks) rates. One hundred and eighty-three children were identified. Children with both a longer diet duration (p=0.004) and lower seizure frequency (p<0.001) were weaned more slowly by our group. There was no significant difference in the incidence of seizures worsening between discontinuation rates. However, there was an increased risk of seizures worsening in those specifically with a 50-99% seizure reduction (30% vs. 8%, p<0.0001) and for that level of seizure improvement, in those who were receiving more anticonvulsants (1.4 vs. 0.8, p=0.01). In summary, there does not appear to be an increased risk of seizure exacerbation with rapid ketogenic diet discontinuations. Those who improved 50-99% and were receiving more anticonvulsants were at the highest risk overall. Discontinuing the ketogenic diet over weeks rather than months appears safe. |
| | |
Authors:
|
Lila T Worden; Zahava Turner; Paula L Pyzik; James E Rubenstein; Eric H Kossoff |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-30 |
Journal Detail:
|
Title: Epilepsy research Volume: - ISSN: 1872-6844 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
|
Johns Hopkins University, School of Medicine, United States. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The influence of manifest strabismus and stereoscopic vision on non-verbal abilities of visually imp...
Next Document: POMC and TP53 genetic variability and risk of basal cell carcinoma of skin: Interaction between host...