Document Detail

Is there a gender difference between ACE gene and race distance?
MedLine Citation:
PMID:  19935855     Owner:  NLM     Status:  MEDLINE    
We aimed to examine the association between the angiotensin I-converting enzyme (ACE) gene (insertion (I) and deletion (D)) polymorphism in Japanese university track athletes and race distance, as well as to evaluate the gender effects on this association. The ACE I/D allele frequency was determined in 277 athletes (176 men, 101 women; aged 19.7 +/- 1.2 years), who were then grouped on the basis of their major competitive race distances (short distance (SD), < or = 200 m; middle distance (MD), 400-800 m, and long distance (LD), > or =1500 m). The ACE I allele frequency increased with the distance (44.4%, 48.4%, and 66.2% for the SD (n = 107), MD (n = 62), and LD (n = 108) groups, respectively; p < 0.001, chi(2) test). On multinomial logistic regression analysis, significant associations between ACE genotype and race distance were observed only in male athletes (ID vs. SD, p = 0.004; ID vs. LD, p = 0.030; II vs. LD, p = 0.001). There was no significant association between ACE genotype and race distance in female athletes. We conclude that the ACE I allele is overrepresented in endurance athletes, and that its frequency varies depending on gender.
Seok-Ki Min; Kazuei Takahashi; Hideaki Ishigami; Kenji Hiranuma; Masuhiko Mizuno; Takashi Ishii; Chang-Sun Kim; Koichi Nakazato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliqu??e, nutrition et m??tabolisme     Volume:  34     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  926-32     Citation Subset:  IM    
Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.
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MeSH Terms
Asian Continental Ancestry Group
Gene Expression Regulation, Enzymologic / physiology*
Peptidyl-Dipeptidase A / genetics*,  metabolism
Physical Endurance / genetics*
Sex Characteristics*
Young Adult
Reg. No./Substance:

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