| Is there a diurnal pattern in the clinical symptoms of HELLP syndrome? | |
| | |
MedLine Citation:
|
PMID: 16581604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine if there is a diurnal pattern in the clinical symptoms of HELLP (Hemolysis, Elevated Liver enzymes, Low Platelets) syndrome. STUDY DESIGN: A retrospective study was performed in 134 pregnancies complicated by HELLP syndrome. The medical records were reviewed to describe each HELLP episode. Time of day was divided into three periods, day, evening, and night. The following parameters were categorized according to the time of day: onset of symptoms, consultation by the doctor, initial blood sampling, diagnosis and decrease of symptoms. Biochemical parameters at clinical presentation and consecutive changes within 24 h were recorded. RESULTS: In 65 pregnancies 77 HELLP episodes were well documented. Times of onset of symptoms and consultation by the doctor were significantly higher during the evening and night (p < 0.001), whereas times of diagnosis and decrease of symptoms occurred significantly more during the day (p < 0.001). In only 49.3% of the cases were diagnostic laboratory criteria met at clinical presentation. This was mainly due to platelet values in excess of 100 x 10(9)/l. Several hours later (median 8 h, range 2-23) the decrease in platelets occurred. CONCLUSIONS: A diurnal pattern exists in the clinical symptoms of HELLP syndrome that is characterized by an exacerbation during the night and recovery during the day. There is a considerable delay between the onset of symptoms and the fulfillment of diagnostic laboratory criteria. |
| | |
Authors:
|
Steven V Koenen; Anjoke J M Huisjes; Jules Dings; Yolanda van der Graaf; Gerard H A Visser; Hein W Bruinse |
Related Documents
:
|
18995894 - The evaluation of corpus luteum blood flow using color-flow doppler ultrasound for earl... 17250584 - Murine pregnancy leads to reduced proliferation of maternal thymocytes and decreased th... 991824 - Serum immunoreactive relaxin and softening of the uterine cervix in pregnant hamsters. 1109944 - Radioimmunoassay of rhesus monkey chorionic gonadotropin. 1766034 - The role of preimplantation sonographic exposure in postimplantation development and pr... 12791334 - Gabapentin exposure in human pregnancy: results from the gabapentin pregnancy registry. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 19 ISSN: 1476-7058 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2006 Feb |
Date Detail:
|
Created Date: 2006-04-03 Completed Date: 2008-01-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
|
Languages: eng Pagination: 93-9 Citation Subset: IM |
Affiliation:
|
Department of Perinatology and Gynaecology, University Medical Centre Utrecht, The Netherlands. svk4@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Circadian Rhythm* Female HELLP Syndrome / blood*, epidemiology, physiopathology* Humans Infant, Newborn Male Medical Records Platelet Count Pregnancy Pregnancy Outcome / epidemiology Referral and Consultation Retrospective Studies Stillbirth Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neighborhood deprivation and preterm birth in Plymouth, UK.
Next Document: Outcome of preterm and term neonates of mothers with malignant diseases diagnosed during pregnancy.