Document Detail


Is there a difference in gastric emptying between myotonic dystrophy type 1 patients with and without gastrointestinal symptoms?
MedLine Citation:
PMID:  23344626     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Gastrointestinal symptoms are frequent complaints in patients with myotonic dystrophy type 1 (MyD1) and may be associated with reduced gastrointestinal motility caused by smooth muscle dysfunction. Although previous studies have found delayed gastric emptying (GE) in MyD1 patients, the relationship between GE and symptoms has been unclear. We investigated GE in 23 MyD1 patients and 20 healthy volunteers using the (13)C-acetate breath test. The MyD1 patients were divided into two groups: those with gastrointestinal symptoms (n = 9) and those without gastrointestinal symptoms (n = 14). The GE function was estimated using the (13)C-acetate breath test as half-emptying time (HET) and peak time of the (13)C-%-dose-excess curve (T (max)). GE (HET and T (max)) was more significantly delayed in patients with MyD1 than in the controls. The GE in MyD1 patients with gastrointestinal symptoms was significantly delayed compared to those without gastrointestinal symptoms. The GE in MyD1 patients with gastrointestinal symptoms was more significantly delayed than in the controls. The GE was significantly delayed in MyD1 patients with gastrointestinal symptoms for >5 years as compared to those with the disease for <5 years, while GE of MyD1 patients without gastrointestinal symptoms did not correlate with the duration of the disease. The GE in MyD1 patients did not correlate with the muscular disability rating scale. These findings suggest that impairment of GE evolves over time and that the progression of delayed GE and skeletal muscle impairment are independent. Smooth muscle impairment may be affected at an earlier stage in MyD1.
Authors:
Yuji Tanaka; Tomohiro Kato; Hiroshi Nishida; Megumi Yamada; Akihiro Koumura; Takeo Sakurai; Yuichi Hayashi; Akio Kimura; Isao Hozumi; Hiroshi Araki; Masahiko Murase; Masahito Nagaki; Hisataka Moriwaki; Takashi Inuzuka
Related Documents :
3239456 - High activities of erythrocyte glutathione peroxidase in patients with the lesch-nyhan ...
23095576 - Simple cystatin c formula compared to serum creatinine-based formulas for estimation of...
23185176 - Cytomegalovirus retinitis after multiple ocular surgeries in an immunocompetent patient.
25065846 - Clinical characteristics of 92 patients with temporal lobe focal cortical dysplasia ide...
19359156 - Predictors of successful weaning from prolonged mechanical ventilation in taiwan.
1745286 - Maximal and minimal motor nerve conduction velocities in patients with motor neuron dis...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Journal of neurology     Volume:  -     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu City, Gifu Prefecture, 501-1194, Japan, yutanaka-gif@umin.net.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing.
Next Document:  Dielectric properties of MSWI bottom ash for non-invasive monitoring of moisture.