Document Detail

Is there a critical gestational age in neutrophil superoxide production activity?
MedLine Citation:
PMID:  7858263     Owner:  NLM     Status:  MEDLINE    
We studied superoxide (O2-) production in neutrophils from 78 normal pregnant women at 7 to 39 weeks' gestation to determine whether there is a critical gestational age in O2- production activity of maternal neutrophils. The O2- production was measured by determining the rate of superoxide dismutase-inhibitable reduction of ferricytochrome c at 550 to 540 nm. A scattergram of neutrophil O2- production value versus gestational age was analyzed using the least median of squares regression, leading to a statistical stratification in which the median values of O2- production for outlying and nonoutlying points were 6.60 nmol/10(6) cells and 2.72 nmol/10(6) cells, respectively. All of the outlying points were concentrated at 19 to 22 gestational weeks. There was the significant difference in FMLP-induced O2- production in neutrophils of nonpregnant subjects when incubated with the sera from 10 cases (selected among 60 cases with nonoutlying points) (3.86 +/- 0.77 nmol/10(6) cells) compared with 5 cases with outlying points (5.62 +/- 1.19 nmol/10(6) cells) (P < .05) These results suggest that during the normal course of pregnancy, the production of O2- from the function of circulating neutrophils can be dissociated from such neutrophil functions as adherence, chemotaxis, and phagocytosis.
K Ishida; K Tsukimori; H Nagata; T Koyanagi; K Akazawa; H Nakano
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood     Volume:  85     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-03-22     Completed Date:  1995-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1331-3     Citation Subset:  AIM; IM    
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Gestational Age*
Immune Tolerance
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Neutrophils / drug effects,  metabolism*
Pregnancy / blood*
Respiratory Burst* / drug effects
Superoxides / blood*
Reg. No./Substance:
11062-77-4/Superoxides; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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