Document Detail

Is there a correlation between testosterone levels and the severity of the disease in male patients with obstructive sleep apnea?
MedLine Citation:
PMID:  21341549     Owner:  NLM     Status:  In-Process    
OBJECTIVES: Obstructive sleep apnea (OSA) is a prevalent disease that can decrease quality of life. The aim of this study was to investigate the relationship between serum testosterone levels and the severity of the disease in patients with OSA.
MATERIAL AND METHODS: Severity of OSA was quantified with apnea-hypopnea index (AHI) which was defined as the total number of apneas and hypopneas per hour of sleep. Thirty-six male patients with mild-to-severe stable OSA and thirty age-matched subjects without OSA were included in this study. Erectile function was assessed by the International Index of Erectile Function (IIEF)-5. The association between severity of OSA and selected comorbidities was evaluated and compared with findings reported in the literature.
RESULTS: Mean serum testosterone levels of OSA and control patients were 462.8 +/- 160.3 ng/dL and 486.9 +/- 163.2 ng/dL, respectively (p > 0.05). There was a significant negative correlation between serum testosterone levels and AHI in patients with OSA (r = - 0,502, p < 0.01). Mean IIEF scores of OSA and control patients were 17.5 +/- 5.9 and 17.4 +/- 4.7, respectively (p > 0.05). Body mass index (BMI) of the OSA patients and control group were as 30.1 +/- 0.8 and 26.9 +/- 0.4, respectively (p < 0.01).
CONCLUSIONS: Serum testosterone levels were negatively correlated with BMI and the severity of OSA. Measuring testosterone level may be an additional helpful indicator in diagnosis of severity and in follow-up of OSA.
Onder Canguven; Banu Salepci; Selami Albayrak; Ahmet Selimoglu; Muhsin Balaban; Mustafa Bulbul
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia     Volume:  82     ISSN:  1124-3562     ISO Abbreviation:  Arch Ital Urol Androl     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-02-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9308247     Medline TA:  Arch Ital Urol Androl     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  IM    
Clinic of Second Urology, Kartal Teaching and Research Hospital, Istanbul, Turkey.
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