| Is there a biological basis for treatment of fibrodysplasia ossificans progressiva with rosiglitazone? Potential benefits and undesired effects. | |
| | |
MedLine Citation:
|
PMID: 20613955 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Thiazolidinediones (TZDs), among which Rosiglitazone, are known agonists of the peroxisome-proliferator-activated receptor gamma (PPARgamma) commonly used for treatment of hyperglycemia. A recently published article describing a case report on a patient affected by Fibrodysplasia Ossificans Progressiva (FOP) treated with Rosiglitazone has prompted interest for careful analysis of the rational basis of such treatment. This article reviews the effects of PPARgamma agonists in relationship with various pathogenic steps that occur during the course of FOP by reviewing the particularly rich literature on the effects of Rosiglitazone, to underscore their relevance to FOP and to consider possible adverse effects. |
| | |
Authors:
|
Renata Bocciardi; Roberto Ravazzolo |
Related Documents
:
|
20856115 - Proton pump inhibitors and severe hypomagnesaemia. 59835 - Imitation: a closer look. 3749275 - Topical hyperbaric oxygenation in the treatment of recalcitrant open wounds. a clinical... 17645395 - The focusing effect of self-evaluation threat in coaction and social comparison. 18338395 - Treatment of juvenile xanthogranuloma. 1495945 - Computer-assisted image interpretation: use of a neural network to differentiate tubula... |
Publication Detail:
|
Type: Journal Article Date: 2010-06-16 |
Journal Detail:
|
Title: PPAR research Volume: 2010 ISSN: 1687-4765 ISO Abbreviation: PPAR Res Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-07-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101269101 Medline TA: PPAR Res Country: United States |
Other Details:
|
Languages: eng Pagination: 541927 Citation Subset: - |
Affiliation:
|
Molecular Genetics Unit, G. Gaslini Institute, 16147 Genova, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Management of the adult with congenital adrenal hyperplasia.
Next Document: Marginal strength of collarless metal ceramic crown.