| Is there a better marker of cardiovascular risk than LDL cholesterol? Apolipoproteins B and A-I--new risk factors and targets for therapy. | |
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MedLine Citation:
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PMID: 17631989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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LDL (Low Density Lipoprotein) is considered the major atherogenic lipoprotein whereas HDL (High Density Lipoprotein) is anti-atherogenic. In recent years also non-HDL cholesterol as well as TG (triglycerides) are included in guidelines defining cardiovascular (CV) risk and target values during lipid lowering treatment. In recent years apolipoproteins (apo) B, reflecting atherogenic, and apoA-I reflecting anti-atherogenic lipoproteins, have been shown to be superior to conventional lipids in predicting risk and reduction of events in lipid lowering trials using statins. These new data are reviewed. The apoB/apoA-I ratio, which reflects the cholesterol balance of the "bad" and "good" lipids, is a simple and accurate summary index of CV risk and it is better than the conventional LDL and other lipids as a risk marker and target for therapy. |
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Authors:
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Göran Walldius; Ingmar Jungner |
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Publication Detail:
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Type: Journal Article Date: 2007-07-16 |
Journal Detail:
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Title: Nutrition, metabolism, and cardiovascular diseases : NMCD Volume: 17 ISSN: 1590-3729 ISO Abbreviation: Nutr Metab Cardiovasc Dis Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-08-28 Completed Date: 2007-09-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111474 Medline TA: Nutr Metab Cardiovasc Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 565-71 Citation Subset: IM |
Affiliation:
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King Gustaf V Research Institute, Karolinska Institute, Stockholm, Sweden; AstraZeneca, Södertälje, Sweden. goran.walldius@astrazeneca.com <goran.walldius@astrazeneca.com> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoprotein A-I
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blood* Apolipoproteins B / blood* Biological Markers / blood Cardiovascular Diseases / blood*, prevention & control* Cholesterol, LDL / blood Evidence-Based Medicine Humans Practice Guidelines as Topic Risk Factors Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Biological Markers; 0/Cholesterol, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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