Document Detail

Is there a best way to set tidal volume for mechanical ventilatory support?
MedLine Citation:
PMID:  18440432     Owner:  NLM     Status:  MEDLINE    
Tidal breaths are an important component of mechanical ventilation. However, an inappropriate tidal volume setting can overstretch and injure the lung. Maximal stretch, tidal stretch, frequency of stretch, and rate of stretch are all implicated in such injury. Clinical trials have shown that limiting maximal and tidal stretch improves outcomes, even if gas exchange is partially compromised. Thus, current strategies should focus on limiting tidal and maximal stretch as much as possible.
Neil R MacIntyre
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Clinics in chest medicine     Volume:  29     ISSN:  0272-5231     ISO Abbreviation:  Clin. Chest Med.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907612     Medline TA:  Clin Chest Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-31, v     Citation Subset:  IM    
Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Room 1120, Box 3911, Erwin Road, Durham, NC 27710, USA.
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MeSH Terms
Lung / physiology
Pulmonary Gas Exchange
Respiration, Artificial*
Tidal Volume*

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