Document Detail

Is there an association between maternal ABO and rhesus blood groups and the first-trimester serum markers free beta-hCG and PAPP-A used for the detection of fetal aneuploidy?
MedLine Citation:
PMID:  17154335     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate whether first-trimester levels of PAPP-A and serum free-beta-human chorionic gonadotrophin (free beta-hCG) vary with maternal blood group and rhesus status and to assess whether this has implications for first-trimester screening for chromosomal anomalies. METHODS: Blood group and rhesus status information was extracted from birth records for women undergoing first-trimester screening. The birth records were combined with prenatal screening records by an in-house developed record linkage software. In 2252 singleton pregnancies of normal obstetric outcome, the median weight-corrected, ethnicity-corrected and smoking-corrected MoM were compared in the various blood groups, using t-tests after log10 transformation of the marker MoM against the whole study group. RESULTS: Only those women with a B rhesus positive blood group had statistically significant higher MoM levels of PAPP-A (0.995 v 0.937). CONCLUSIONS: A larger study is required to establish the validity of this increase in PAPP-A in the B rhesus positive group. If this can be substantiated, the elevation in PAPP-A in this group may require correction when screening for chromosomal anomalies.
Nicholas J Cowans; Kevin Spencer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  27     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  64-7     Citation Subset:  IM    
Copyright Information:
Copyright 2007 John Wiley & Sons, Ltd.
Prenatal Screening Unit, Department of Clinical Biochemistry, Harold Wood Hospital, Romford, Essex RM3 0BE.
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MeSH Terms
ABO Blood-Group System / chemistry*
Biological Markers / analysis
Chorionic Gonadotropin, beta Subunit, Human / analysis*
Chromosome Aberrations / embryology
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / analysis*
Prenatal Diagnosis*
Rh-Hr Blood-Group System / chemistry*
Reg. No./Substance:
0/ABO Blood-Group System; 0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Rh-Hr Blood-Group System; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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