Document Detail

Is there any relationship between cytokine spectrum of breast milk and occurence of eosinophilic colitis?
MedLine Citation:
PMID:  20557294     Owner:  NLM     Status:  In-Process    
AIM: The aim of our study was to analyse cytokine composition of human milk and its relationship to the development of eosinophilic colitis (EC).
METHODS: Cytokines were measured by ELISA method in breast milk of 20 mothers of infants who developed EC and 20 controls.
RESULTS: We found significantly higher concentrations of interferon-gamma (IFN-gamma) (Th1 cytokine) in breast milk received by EC infants compared to controls (p = 0.0004). In contrary, IL-18 (Th1-inducing cytokine) was significantly higher in breast milk received by healthy infants comparing to EC infants (p = 0.001). Regulatory cytokine transforming growth factor beta1 (TGF-beta1) showed higher concentrations in breast milk received by healthy infants, although the difference from EC group was not significant (p = 0.072).
CONCLUSION: The results of our study showed that infants with EC were receiving breast milk with a possibly risky cytokine pattern indicating cytokine imbalance, impaired immunoregulation and the early Th1 shift.
Marianna Durilova; Katerina Stechova; Lenka Petruzelkova; Vendula Stavikova; Tereza Ulmannova; Jiri Nevoral
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-06
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  99     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1666-70     Citation Subset:  IM    
Copyright Information:
© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Paediatrica.
Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
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