| Is there any difference in target intraocular pressure for exfoliative glaucoma patients with cardiovascular disease history? | |
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MedLine Citation:
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PMID: 20544681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate if patients with exfoliation glaucoma (XFG) with cardiovascular disease (CVD) require different target intraocular pressure (IOP) compared to patients with XFG with no CVD for long-term stability. METHODS: A retrospective, multicenter, observational cohort analysis included consecutive patients with XFG from 9 European academic centers, with a minimum of 5 years follow-up. RESULTS: In 201 patients, there was a statistical difference between progressed and non-progressed patients in mean (p=0.0049) and peak (p=0.015) IOP, variance of IOP (p=0.028), and number of medicine changes/year (p=0.0037). At a mean IOP ≥22 mmHg, patients progressed in 84% (32/38), between 14 and 21 mmHg in 54% (81/151), and at ≤13 mmHg in 33% (4/12). There was no difference in the rate of progression between groups based on CVD history (p=0.65). However, IOP that allowed ≤50% progression rate for patients with mild or no CVD was ≤20-21 mmHg and ≤18 mmHg for patients with severe disease. Further, at IOP ≥20 mmHg, 8% (1/12) of patients with severe CVD remained stable in contrast to 38% (16/42) of patients with mild and 21% (4/19) with no CVD history (p=0.0093). By multivariant regression analysis of the IOP and CVD measures, mean IOP was a risk factor for progression (p=0.0097). CONCLUSIONS: Although IOP is the main determinant of progression in XFG under treatment, history of severe CVD should be further investigated as potential risk factor for glaucomatous progression. |
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Authors:
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Gábor Holló; Barbara Cvenkel; Miguel A Teus; Murat T Irkec; Yuri S Astakhov; Dorin Chiselita; Nataliya Petkova; Ivana Liehneová; Bartlomiej J Kaluzny; Péter Kóthy; Banu Bozkurt; Evgeny L Akopov; Jeanette A Stewart; Michael S Kristoffersen; Caroline J Kristoffersen; William C Stewart |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: European journal of ophthalmology Volume: 20 ISSN: 1724-6016 ISO Abbreviation: Eur J Ophthalmol Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110772 Medline TA: Eur J Ophthalmol Country: Italy |
Other Details:
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Languages: eng Pagination: 1000-6 Citation Subset: IM |
Affiliation:
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Semmelweis University, Budapest, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antihypertensive Agents / administration & dosage Cardiovascular Diseases / complications, drug therapy, physiopathology* Cohort Studies Disease Progression Exfoliation Syndrome / complications, drug therapy, physiopathology* Female Follow-Up Studies Glaucoma, Open-Angle / complications, drug therapy, physiopathology* Humans Intraocular Pressure / drug effects, physiology* Male Retrospective Studies Risk Factors Tonometry, Ocular Visual Acuity / physiology Visual Fields / physiology |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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