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Is there any correlation between HLA-DR expression in laryngeal mucosa and interleukin gene variation in sudden infant death syndrome?
MedLine Citation:
PMID:  23186119     Owner:  NLM     Status:  Publisher    
AIM: The mucosal immune system and cytokines are activated in a large proportion of cases of sudden infant death syndrome (SIDS). Our aim was to search for a possible association between cytokine polymorphisms and immunestimulation of the laryngeal mucosal in SIDS. METHODS: HLA-DR expression in laryngeal mucosal glands and surface epithelium in 97 SIDS victims were evaluated applying a semi- quantitative scoring system. The findings were related to cytokine gene polymorphisms as well as to the level of various cytokines in the cerebrospinal fluid (CSF). A risk score was established: a score of 0 prepresenting negative HLA-DR, supine position and no fever prior to death. RESULTS: The IL-6 -176CG/CC genotype was found in 92.3% of the SIDS cases with positive score for all risk factors (p=0.01). Infants with high HLA-DR score had high levels of IL-6 in the cerebrospinal fluid (>30 μg/l) (p=0,005). Furthermore, the IL-8 SNPs -781 CT/TT genotypes and -251 AA/AT genotypes were observed in 93% of the SIDS cases with one or more of the risk factors present compared to SIDS cases no risk factors reported (p=0,003 and p=0,016 respectively). CONCLUSION: This study adds further evidence to the hypothesis that there are genetically associated disturbances of immunological homeostasis in SIDS. ©2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica.
Linda Ferrante; Siri H Opdal; Ashild Vege; Torleiv O Rognum
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-27
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica.
Norwegian Institute of Public Health, Department of Forensic Pathology and clinical Forensic Medicine, Oslo, Norway.
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