Document Detail

The therapeutic potential of mesenchymal stem cells. Cell- & tissue-based therapy.
MedLine Citation:
PMID:  17665987     Owner:  NLM     Status:  MEDLINE    
Mesenchymal stem cells (MSCs) are multipotent cells with a number of potential therapeutic applications. At present, they are being used in a clinical trial for the treatment of myocardial infarction and are being studied as a therapy for other vascular disorders. Treatments of neurologic disorders and anticancer therapy with MSCs have progressed in light of the migratory properties of MSCs to brain injury and tumors. The osteogenic potential of MSCs is being exploited in work investigating their use in bone regeneration therapy, and the immunomodulatory function of MSCs is being evaluated as a possible therapy for graft-versus-host disease. Here, the authors review recent work contributing to the knowledge of MSC biology and the advances in gene therapy and tissue regeneration using MSCs.
Sonia C Picinich; Pravin J Mishra; Prasun J Mishra; John Glod; Debabrata Banerjee
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  7     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  965-73     Citation Subset:  IM    
University of Medicine and Dentistry of New Jersey, Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.
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MeSH Terms
Bone Regeneration
Graft vs Host Disease / therapy
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells / cytology
Myocardial Infarction / therapy
Neoplasms / therapy
Osteoarthritis / therapy
Osteogenesis Imperfecta / therapy
Parkinson Disease / therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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